Association of the APC gene product with beta-catenin
摘要：
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton protein that was purified and identified by sequencing as beta-catenin, a protein that binds to the cell adhesion molecule E-cadherin. An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion.
展开
关键词：
Humans Cell Line Tumor Cells, Cultured Colonic Neoplasms Cytoskeletal Proteins Trans-Activators Cadherins Neoplasm Proteins Antibodies Precipitin Tests
DOI：
10.1126/science.8259518
被引量：
年份：
1993
BMJ
Semantic Scholar
万方医学
dx.doi.org
Cell Press
查看更多
Europe PMC
JSTOR
NCBI
Oxford Univ Press
JBC
AACR
dialnet.unirioja.es
adsabs.harvard.edu
ResearchGate
ProQuest
EBSCO
molbiolcell.org
gastrojournal.org
jcs.biologists.org
ajpgi.physiology.org
jcb.rupress.org
genesdev.cshlp.org
scienceopen.com
jp.physoc.org
fasebj.org
publishing.rcseng.ac.uk
onacademic.com
emboj.embopress.org
go.galegroup.com
ganino.com
(全网免费下载)
mendeley.com
www.socolar.com
jacionline.org
scindeks.ceon.rs
sciencemag.org
199.171.202.195
ejcancer.com
elifesciences.org
seminoncol.org
SAGE
cghjournal.org
genetics.org
mcb.asm.org
highbeam.com
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
