Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
摘要：
MyD88, IRAK4 and IRAK2 are critical signaling mediators of the TLR/IL1-R superfamily. Here we report the crystal structure of the MyD88: IRAK4: IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs. Assembly of this helical signaling tower is hierarchical, in which MyD88 recruits IRAK4 and the MyD88: IRAK4 complex recruits the IRAK4 substrates IRAK2 or the related IRAK1. Formation of these Myddosome complexes brings the kinase domains of IRAKs into proximity for phosphorylation and activation. Composite binding sites are required for recruitment of the individual DDs in the complex, which are confirmed by mutagenesis and previously identified signaling mutations. Specificities in Myddosome formation are dictated by both molecular complementarity and correspondence of surface electrostatics. The MyD88: IRAK4: IRAK2 complex provides a template for Toll signaling inDrosophilaand an elegant mechanism for versatile assembly and regulation of DD complexes in signal transduction.
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关键词：
Humans Signal Transduction Protein Structure, Tertiary Interleukin-1 Receptor-Associated Kinases Myeloid Differentiation Factor 88 Receptors, Interleukin-1 Models, Molecular Toll-Like Receptors
DOI：
10.1038/nature09121
被引量：
年份：
2010
Nature
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