Sulfated N-(carboxymethyl)chitosans: Novel blood anticoagulants
摘要：
N-(Carboxymethyl)chitosan was subjected to sulfation in a mixture of concentrated sulfuric acid (oleum) and N,N-dimethylformamide, under anhydrous conditions. The resulting product contained 11% of sulfur and degree of substitution: N-acetyl, 42%; N-carboxymethyl, 58%; and sulfate, 100%. Sonication of the sulfated N-(carboxymethyl)chitosan gave two main fractions whose molecular weights were 39,000 and 80,000. In human blood, complexes of sulfated N-(carboxymethyl) chitosan and antithrombin inhibited both thrombin and factor Xa, and produced neither hemolysis nor alterations in erythrocytes and lymphocytes. Sulfated N-(carboxymethyl)chitosan is therefore proposed as a blood anticoagulant.
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关键词：
Humans Chitin Thrombin Factor X Anticoagulants Blood Coagulation Indicators and Reagents Factor Xa
DOI：
10.1016/0008-6215(84)85380-X
被引量：
年份：
1984
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