The multifaceted roles of nitric oxide in cancer.
摘要：
The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chemical species such as those generated under oxidative stress. Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer. Chronic inflammation can lead to the production of chemical intermediates, among them NO, which in turn can mediate damage to DNA. Yet, NO also appears to be critical for the tumoricidal activity of the immune system. Furthermore, NO can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. This report will discuss how the chemistry of NO may impact the initiation and progression stages of cancer.
展开
DOI：
10.1093/carcin/19.5.711
被引量：
年份：
1998
Wiley
academic.oup.com
doi.org
万方医学
Semantic Scholar
(全网免费下载)
查看更多
dx.doi.org
Ingenta
Europe PMC
NCBI
NCBI
Oxford Univ Press
(全网免费下载)
Oxford Univ Press
JBC
AACR
ResearchGate
ProQuest
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
mysciencework.com
jleukbio.org
ajplung.physiology.org
nejm.org
jacionline.org
www.socolar.com
paperity.org
onAcademic
deepdyve.com
cghjournal.org
mendeley.com
d.scholar.cnki.net
scindeks.ceon.rs
jimmunol.org
bioscirep.org
ar.iiarjournals.org
ajcn.nutrition.org
jpet.aspetjournals.org
mcb.asm.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
