摘要：

Emphysema and small airway obstruction are the pathological hallmarks of chronic obstructive pulmonary disease (COPD). The aim of this pilot study in a small group of chronic obstructive pulmonary disease (COPD) patients was to quantify hyperpolarized helium-3 (He) magnetic resonance imaging (MRI) functional and structural measurements and to explore the potential role for He MRI in detecting the lung structural and functional COPD phenotypes.Materials and methodsWe evaluated 20 ex-smokers with stage I ( = 1), stage II ( = 9) and stage III COPD ( = 10). All subjects underwent same-day plethysmography, spirometry, H MRI and hyperpolarized He MRI at 3.0 T. He ventilation defect percent (VDP) was generated from He static ventilation images and H thoracic images and the He apparent diffusion coefficient (ADC) was derived from diffusion-weighted MRI.ResultsBased on the relative contribution of normalized ADC and VDP, there was evidence of a predominant He MRI measurement in seven patients ( = 3 mainly ventilation defects or VDP dominant (VD),  = 4 mainly increased ADC or ADC dominant (AD)). Analysis of variance (ANOVA) showed significantly lower ADC for subjects with predominantly elevated VDP ( = 0.02 compared to subjects with predominantly elevated ADC;  = 0.008 compared to mixed group) and significantly decreased VDP for subjects with predominantly elevated ADC ( = 0.003, compared to mixed group).ConclusionIn this small pilot study, a preliminary analysis shows the potential for He MRI to categorize or phenotype COPD ex-smokers, providing good evidence of feasibility for larger prospective studies.

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