IAP proteins: blocking the road to death's door.

阅读量:

185

作者:

GS SalvesenCS Duckett

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摘要:

The 'inhibitor of apoptosis' (IAP) gene family, which was discovered less than a decade ago, encodes a group of structurally related proteins that, in addition to their ability to suppress apoptotic cell death, are involved in an increasing number of seemingly unrelated cellular functions. Here, we review the functional and structural properties of this fascinating group of proteins, and of several recently identified IAP-binding factors that regulate IAP function.

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DOI:

10.1038/nrm830

被引量:

4062

年份:

2002

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2010
被引量:376

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