IAP proteins: blocking the road to death's door.
摘要:
The 'inhibitor of apoptosis' (IAP) gene family, which was discovered less than a decade ago, encodes a group of structurally related proteins that, in addition to their ability to suppress apoptotic cell death, are involved in an increasing number of seemingly unrelated cellular functions. Here, we review the functional and structural properties of this fascinating group of proteins, and of several recently identified IAP-binding factors that regulate IAP function.
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关键词:
Animals Humans Proteins Insect Proteins Cysteine Proteinase Inhibitors Apoptosis Gene Expression Regulation Binding Sites Inhibitor of Apoptosis Proteins
DOI:
10.1038/nrm830
被引量:
年份:
2002












































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