摘要：

The pathogenesis of severe acute pancreatitis isvery complicated.It is a multifactorial as well asmultifaceted disease.First of all,the etiologicagents initiate the pancreatic acinar injury by releaseof pancreatic enzymes and overstimulation ofmacrophages and neutrophils,then the cytokinesand inflammatory mediators are liberated.There is

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