microRNAs: A Safeguard against Turmoil?

阅读量:

76

作者:

AKL LeungPA Sharp

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摘要:

Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.

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关键词:

IGF-II IGFBP-2 PTEN

DOI:

10.1016/j.cell.2007.08.010

被引量:

514

年份:

2007

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来源期刊

Cell
2007/09/01

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2008
被引量:86

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