The complexity of the GABAA receptor shapes unique pharmacological profiles.
摘要：
Gamma-amino butyric acid (GABA) is the most abundant inhibitory neurotransmitter in the central nervous system (CNS) and many physiological actions are modulated by GABA A receptors. These chloride channels can be opened by GABA and are a target for a variety of important drugs such as benzodiazepines, barbiturates, neuroactive steroids, convulsants and anaesthetics. GABA A receptors are involved in anxiety, feeding and drinking behaviour, circadian rhythm, cognition, vigilance, and learning and memory. Moreover, deficits in the functional expression of GABA A receptors have been implicated in multiple neurological and psychiatric diseases. This review aims to discuss the unique physiological and pharmacological properties of the multitude of GABA A receptor subtypes present in the CNS, making this receptor an important target for novel rational drug therapy.
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关键词：
Animals Humans Mice Brain gamma-Aminobutyric Acid Benzodiazepines Receptors, GABA-A Drug Delivery Systems Binding Sites Mice, Transgenic
DOI：
10.1016/j.drudis.2009.06.009
被引量：
年份：
2009
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