Estrogen-binding substances of target tissues.
摘要：
A variety of evidence supports the concept that the interaction of estradiol with uterine tissue takes place by a two stage mechanism. The hormone associates spontaneously with an extranuclear protein to form an 8S complex, made up of 4S subunits, which possesses a strong affinity for nuclei. In the nucleus a new estradiol-protein complex, extractable as a 5S unit, is formed from the 8S complex by a temperature-dependent process which consumes 8S receptor. The concept of "induced derepression" is proposed to explain how the nuclear transformation of 4S to a 5S estradiol-protein complex might initiate uterine growth.
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DOI：
10.1016/0039-128X(69)90053-1
被引量：
年份：
1969
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