Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP1 and MRP2
摘要：
Transfection of multidrug resistance proteins (MRPs) MRP1 and MRP2 in human ovarian carcinoma 2008 cells conferred a marked level of resistance to short-term (1-4 h) exposure to the polyglutamatable antifolates methotrexate (MTX; 21-74-fold), ZD1694 (4-138-fold), and GW1843 (101-156-fold). Evidence for MRP-mediated antifolate efflux relies upon the following findings: (a) a 2-3.3-fold lower accumulation of [3H]MTX and subsequent reduced formation of long-chain polyglutamate forms of MTX; (b) reversal of MTX resistance by probenecid in both transfectants, and (c) ATP-dependent uptake of [3H]MTX in inside-out vesicles of MRP1 and MRP2 transfectants. This report provides a mechanistic basis for resistance to polyglutamatable antifolates through an MRP-mediated drug extrusion.
展开
DOI：
doi:http://dx.doi.org/
被引量：
年份：
1999
Taylor & Francis
BMJ
Semantic Scholar
(全网免费下载)
Semantic Scholar
万方医学
查看更多
NCBI
Oxford Univ Press
NCBI
Cell Press
AACR
(全网免费下载)
AACR
(全网免费下载)
AACR
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
学术范
(全网免费下载)
scienceopen.com
fasebj.org
学术范
theoncologist.alphamedpress.org
pharmgkb.org
narcis.nl
hdl.handle.net
mysciencework.com
deepdyve.com
united-academics.org
core.ac.uk
dare.ubvu.vu.nl
dare.uva.nl
ajtmh.org
SAGE
cghjournal.org
aac.asm.org
mendeley.com
dmd.aspetjournals.org
jeb.biologists.org
ajpgi.physiology.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
