The spectrum of benign to malignant lymphoproliferation in Sjgren's syndrome.

来自 EBSCO

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摘要：

Clinical and pathological evidence suggests that a wide spectrum of lymphoproliferation exists in Sjgren's syndrome (SS), from benign disease with lymphoid infiltrates confined to glandular tissue on the one end, to widespread lymphoreticular malignancy on the other. In the middle of the spectrum are patients threatened by extraglandular extension of lymphoproliferation which is not clinically or histologically malignant and which apparently has the potential to regress with appropriate therapy or to progress to frank neoplasia. Illustrative patients are described. Over thirty other case reports associating 55 with pseudolymphoma, Waldenstrorn's macroglobulinaemia, reticulum cell sarcoma, or other lymphomas appear in the literature, Similar lymphoproliferative processes have been observed in other autoimmune diseases, in certain immune deficiency states, with hydantoin and other anticonvulsant drugs, and in experimental animal models. In SS, as in these other conthtions, it seems likely that a combination of genetic, immunologic, and viral or other unknown environmental factors plays a role in pathogenesis.

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DOI：

10.1177/0275074015605378

被引量：

523

年份：

1972