The role of interleukin|[ndash]|15 in T|[ndash]|cell migration and activation in rheumatoid arthritis
摘要：
Interleukin 15 (IL15) is a novel cytokine with interleukin2like activity. It is also a potent Tlymphocyte chemoattractant. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the presence of activated T lymphocytes, macrophages and synoviocytes in the synovial membrane. The mechanisms of Tcell activation in RA are currently unclear. We report the presence of high concentrations of IL15 in rheumatoid arthritis (RA) synovial fluid and have demonstrated its expression in the synovial membrane lining layer by immunohistochemistry. RA synovial fluids were found to contain chemotactic activity, which was attributable in part to the presence of IL15. Moreover, in a murine model, injection of recombinant IL15 was found to induce a local tissue inflammatory infiltrate consisting predominantly of T lymphocytes. Synovial fluid T lymphocytes proliferate in response to IL15, demonstrating that continued responsiveness to IL15 is a feature of T cells after entry into the synovial compartment. These data suggest that IL15 can recruit and activate T lymphocytes into the synovial membrane, thereby contributing to RA pathogenesis.
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DOI：
10.1038/nm0296-175
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年份：
1996
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