Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
摘要：
The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.
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关键词：
Humans Reproducibility of Results Gene Expression Profiling Genomics Internet Software Information Storage and Retrieval Neoplasms Genetic Predisposition to Disease Gene Regulatory Networks
DOI：
10.1126/scisignal.2004088
被引量：
年份：
2013
Taylor & Francis
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Semantic Scholar
掌桥科研
万方医学
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