The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.
摘要：
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms for controlling cell survival, differentiation, proliferation, metabolism, and motility in response to extracellular cues. Components of these pathways were among the first to be discovered when scientists began cloning proto-oncogenes and purifying cellular kinase activities in the 1980s. Ras-ERK and PI3K-mTOR were originally modeled as linear signaling conduits activated by different stimuli, yet even early experiments hinted that they might intersect to regulate each other and co-regulate downstream functions. The extent of this cross-talk and its significance in cancer therapeutics are now becoming clear.
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关键词：
Humans ras Proteins Extracellular Signal-Regulated MAP Kinases Signal Transduction Phosphatidylinositol 3-Kinase TOR Serine-Threonine Kinases
DOI：
10.1016/j.tibs.2011.03.006
被引量：
年份：
2011
Elsevier
国家科技图书文献中心
(权威机构)
掌桥科研
Ingenta
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