Using the Rat as a Cholera "Model"
摘要：
AFTER the discovery of the Vibrio cholerae by Koch in 1883, many investigators attempted to develop animal models in a wide variety of species 1 . Results were erratic and it was not until 1953 that De and Chatterje 2 developed the ileal loop in adult rabbits as a model which gave consistent results. Shortly afterwards, Dutta and Habbu 3 developed the "suckling bunny" model which also gave consistent results. Since then, these two models have been widely used to study the effects of vibrios and their products on fluid accumulation into the gut lumen. Recently, Carpenter and his colleagues 4 developed an animal model using dogs with chronic Thiry-Vella loops in the jejunum and ileum. We report now that the rat can also be used as a cholera model.
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DOI：
10.1038/220814a0
被引量：
年份：
1968
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