Innate and adaptive immunity in inflammatory bowel disease
摘要：
Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a cross-regulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets.
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DOI：
10.3748/wjg.v17.i27.3178
被引量：
年份：
2011
Elsevier
Taylor & Francis
维普期刊专业版
万方医学
掌桥科研
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