Structure and function of adenosine receptors and their genes
摘要:
Four adenosine receptors have been cloned from many mammalian and some non-mammalian species. In each case the translated part of the receptor is encoded by two separate exons. Two separate promoters regulate the A 1 receptor expression, and a similar situation may pertain also for the other receptors. The receptors are expressed in a cell and tissue specific manner, even though A 1 and A 2B receptors are found in many different cell types. Emerging data indicate that the receptor protein is targeted to specific parts of the cell. A 1 and A 3 receptors activate the G i family of G proteins, whereas A 2A and A 2B receptors activate the G s family. However, other G proteins can also be activated even though the physiological significance of this is unknown. Following the activation of G proteins several cellular effector pathways can be affected. Signaling via adenosine receptors is also known to interact in functionally important ways with signaling initiated via other receptors.
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DOI:
10.1007/s002100000313
被引量:
年份:
2000


































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