Structure and function of adenosine receptors and their genes

来自 EBSCO

阅读量:

208

作者:

BB FredholmG ArslanL HalldnerB KullG SchulteW Wasserman

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摘要:

Four adenosine receptors have been cloned from many mammalian and some non-mammalian species. In each case the translated part of the receptor is encoded by two separate exons. Two separate promoters regulate the A 1 receptor expression, and a similar situation may pertain also for the other receptors. The receptors are expressed in a cell and tissue specific manner, even though A 1 and A 2B receptors are found in many different cell types. Emerging data indicate that the receptor protein is targeted to specific parts of the cell. A 1 and A 3 receptors activate the G i family of G proteins, whereas A 2A and A 2B receptors activate the G s family. However, other G proteins can also be activated even though the physiological significance of this is unknown. Following the activation of G proteins several cellular effector pathways can be affected. Signaling via adenosine receptors is also known to interact in functionally important ways with signaling initiated via other receptors.

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DOI:

10.1007/s002100000313

被引量:

990

年份:

2000

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2010
被引量:91

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