Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex
摘要：
Genetic analysis of apoptosis in the nematode Caenorhabditis elegans has revealed the cell death machine to be composed of three core interacting components. CED-4 (equivalent to mammalian Apaf-1) is a nucleotide binding molecule that complexes with the zymogen form of the death protease CED-3, leading to its autoactivation and cell death. CED-9 blocks death by complexing with CED-4 and attenuating its ability to promote CED-3 activation. An equivalent ternary complex was found to be present in mammalian cells involving Apaf-1, the mammalian death protease caspase-9, and Bcl-XL, an anti-apoptotic member of the Bcl-2 family. Consistent with a central role for caspase-9, a dominant negative form effectively inhibited cell death initiated by a wide variety of inducers.
展开
关键词：
protein tyrosine phosphorylation/dephosphorylation Xenopus laevis fertilization egg activation genistein
DOI：
10.1074/jbc.273.10.5841
被引量：
年份：
1998
Elsevier
国家科技图书文献中心
(权威机构)
掌桥科研
Semantic Scholar
万方医学
查看更多
dx.doi.org
Europe PMC
NCBI
NCBI
Cell Press
AACR
JBC
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
jimmunol.org
ar.iiarjournals.org
genesdev.cshlp.org
jcs.biologists.org
学术范
学术范
(全网免费下载)
钛学术
mendeley.com
jleukbio.org
fasebj.org
circres.ahajournals.org
jem.rupress.org
ajpgi.physiology.org
jvi.asm.org
seminoncol.org
cghjournal.org
钛学术
(全网免费下载)
emboj.embopress.org
onacademic.com
readcube.com
www.socolar.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
