Rimonabant, a Selective Cannabinoid CB1 Receptor Antagonist, Inhibits Atherosclerosis in LDL Receptor–Deficient Mice
摘要：
Objective - The objective of this study was to determine whether the potent selective cannabinoid receptor-1 antagonist rimonabant has antiatherosclerotic properties. Methods and Results - Rimonabant (50 mg/kg/d in the diet) significantly reduced food intake (from 3.35卤.04 to 2.80卤0.03 g/d), weight gain (from 14.6卤0.7 g to -0.6卤0.3 g), serum total cholesterol (from 8.39卤0.54 to 5.32卤0.18 g/L), ...
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关键词：
animal models antagonists aorta atherosclerosis biochemical receptors cholesterol cytokines diets food intake inflammation
DOI：
10.1161/ATVBAHA.108.168757
被引量：
年份：
2009
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