Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects

来自 EBSCO

阅读量：

192

摘要：

Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata , has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-controlled clinical trials to assess the anti-irritative efficacy of cosmetic formulations containing LicA in a post-shaving skin irritation model and on UV-induced erythema formation. The clinical trials were accompanied by a series of in vitro experiments to characterize anti-inflammatory properties of LicA on several dermatologically relevant cell types. Topical LicA causes a highly significant reduction in erythema relative to the vehicle control in both the shave- and UV-induced erythema tests, demonstrating the anti-irritative properties of LicA. Furthermore, LicA is a potent inhibitor of pro-inflammatory in vitro responses, including N -formyl-MET-LEU-PHE (fMLP)- or zymosan-induced oxidative burst of granulocytes, UVB-induced PGE 2 release by keratinocytes, lipopolysaccharide (LPS)-induced PGE 2 release by adult dermal fibroblasts, fMLP-induced LTB 4 release by granulocytes, and LPS-induced IL-6/TNF-α secretion by monocyte-derived dendritic cells. The reported data suggest therapeutic skin care benefits from LicA when applied to sensitive or irritated skin.

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关键词：

Anti-inflammatory agents Non-steroidal Clinical trial Dermatologic agents Allergy and immunology Licochalcone A

DOI：

10.1007/s00403-006-0654-4

被引量：

141

年份：

2006