Immunosuppression in allogeneic murine tumour system. A model for the study of antilymphocyte serum.
摘要：
In Swiss mice, previously immunised with sarcoma 180, a second implant of the same tumour failed to establish itself. Treatment of such animals, during the period of immunisation, with rabbit antisera to mouse thymus, spleen (A.L.S.), and brain suppressed the development of immunity and permitted growth of the second tumour implant. The growth of the tumour, expressed as a tumour index (the average tumour weight multiplied by the proportion of mice with tumour take) was related to the immunosuppresive activity of a specific preparation of A.L.S. This experi- mental model offers many advantages in a study of the properties, purification, and mode of action of A.L.S.
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DOI：
10.1016/S0140-6736(68)92562-2
被引量：
年份：
1960
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