FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis
摘要：
We identified and cloned a novel human protein that contains FADD/Mort1 death effector domain homology regions, designated FLAME-1. FLAME-1, although most similar in structure to Mch4 and Mch5, does not possess caspase activity but can interact specifically with FADD, Mch4, and Mch5. Interestingly, FLAME-1 is recruited to the Fas receptor complex and can abrogate Fas/TNFR-induced apoptosis upon expression in FasL/tumor necrosis factor-sensitive MCF-7 cells, possibly by acting as a dominant-negative inhibitor. These findings identify a novel endogenous control point that regulates Fas/TNFR1-mediated apoptosis.
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关键词：
Humans Intracellular Signaling Peptides and Proteins Adaptor Proteins, Signal Transducing TNF Receptor-Associated Factor 1 Cysteine Endopeptidases Caspases Proteins Membrane Glycoproteins Cloning, Molecular Ultraviolet Rays
DOI：
10.1074/jbc.272.30.18542
被引量：
年份：
1997
Elsevier
BMJ
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