Asymmetric addition of arylboronic acids to glyoxylate catalyzed by a ruthenium/Me-BIPAM complex
摘要：
The enantioselective synthesis of α-hydroxy esters by ruthenium-catalyzed 1,2-addition of arylboronic acids totert-butyl glyoxylate is described. The use of RuCl2(PPh3)3with (R,R)-Me-BIPAM gave optically active mandelic acids of up to 99% ee. Addition of a fluoride salt such as potassium fluoride (KF) or caesium fluoride (CsF) was effective for achieving high enantioselectivities.
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关键词：
hydroxycarboxylic acids (ether carboxylic acids) and esters (benzene compounds) diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) C‐C bond formation
DOI：
10.1039/c2cc17339e
被引量：
年份：
2012
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