Asymmetric addition of arylboronic acids to glyoxylate catalyzed by a ruthenium/Me-BIPAM complex

来自 Wiley

阅读量:

30

作者:

Y YamamotoT ShiraiN Miyaura

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摘要:

The enantioselective synthesis of α-hydroxy esters by ruthenium-catalyzed 1,2-addition of arylboronic acids totert-butyl glyoxylate is described. The use of RuCl2(PPh3)3with (R,R)-Me-BIPAM gave optically active mandelic acids of up to 99% ee. Addition of a fluoride salt such as potassium fluoride (KF) or caesium fluoride (CsF) was effective for achieving high enantioselectivities.

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DOI:

10.1039/c2cc17339e

被引量:

33

年份:

2012

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来源期刊

ChemInform
2012/07/10

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2014
被引量:11

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