Inositol trisphosphate and calcium signalling

来自 Nature

阅读量:

286

作者:

MICHAEL J. BERRIDGE

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摘要:

Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.

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DOI:

10.1111/j.1749-6632.1995.tb26646.x

被引量:

1.2万

年份:

1995

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1996
被引量:943

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