Major depressive disorder and disease activity in systemic lupus erythematosus

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作者：

FG Nery，EF Borba，JP Hatch，JC Soares，E Bonfá，FL Neto

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摘要：

The association between psychosocial factors and systemic lupus erythematosus (SLE) is still a matter of discussion. Mood disorders may represent neuropsychiatric manifestations of SLE disease activity or may be a consequence of the stress of having a chronic major disease. We examined the hypothesis that SLE disease activity is related to the presence and severity of major depression in patients with SLE. Seventy-one patients with SLE were evaluated for the presence and intensity of major depressive disorder, psychosocial stressors, functional disability, SLE disease activity, and cumulative damage. Patients with major depression presented a trend toward having greater severity of SLE disease activity compared with those without major depression ( = .056). Major depression was also associated with life events ( = .017) and hassles ( = 0.26, = .026) and with functional disability ( = 0.46, = .014). In conclusion, these results support the hypothesis that SLE disease activity is a potential risk factor for the presence and severity of major depression in patients with SLE. Whether major depression in active SLE is a central nervous system manifestation of the disease that is mediated by an autoimmune mechanism deserves further research.

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关键词：

Shared Interest Group small group intervention loneliness elderly independent living facilities

DOI：

10.1016/j.comppsych.2006.04.002

被引量：

232

年份：

2007