The controlled porosity osmotic pump
摘要：
The zero-order release of water soluble, osmotically active agents from tablets coated with controlled porosity walls has been investigated. The walls were sponge-like in appearance and substantially permeable to both water and dissolved solutes. The rate of release was a function of the wall thickness, level of leachable additives incorporated and permeability of the polymer component of the walls, the total solubility of the core tablet, the drug load, and the osmotic pressure difference across the wall. Release was insensitive to the pH and degree of agitation in the receptor media. Release was primarily due to an osmotic pump mechanism. Steady-state release rates were calculated from basic water and solute permeabilities of the walls and correlated with actual device performance. The concept of osmotically actuated drug delivery on an equivalent mass per unit surface area basis was demonstrated and extended, as well, to multiparticulate dosage forms.
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DOI：
10.1016/0168-3659(85)90003-3
被引量：
年份：
1985
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