A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1

来自 Wiley

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作者：

C Tran，F Gagnon，KG Wigg，Y Feng，L Gomez，TD Cate-Carter，EN Kerr，LL Field，BJ Kaplan，MW Lovett

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摘要：

Reading disabilities (RD) have a significant genetic basis and have shown linkage to multiple regions including chromosome 15q. Dyslexia susceptibility 1 candidate gene 1 (DYX1C1) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms at the 3G/A and 1249G/T positions showing association with RD. However, subsequent studies have yielded mixed results. We performed a literature review and meta-analysis of the 3G/A and 1249G/T polymorphisms, including new unpublished data from two family-based samples. Ten markers in DYX1C1 were genotyped in the two independently ascertained samples. Single marker and 3G/A:1249G/T haplotype analyses were performed for RD in both samples, and quantitative trait analyses using standardized reading-related measures was performed in one of the samples. For the meta-analysis, we used a random-effects model to summarize studies that tested for association between 3G/A or 1249G/T and RD. No significant association was found between the DYX1C1 SNPs and RD or any of the reading-related measures tested after correction for the number of tests performed. The previously reported risk haplotype (3A:1249T) was not biased in transmission. A total of 9 and 10 study samples were included in the meta-analysis of the 3G/A and 1249G/T polymorphisms, respectively. Neither polymorphism reached statistical significance, but the heterogeneity for the 1249G/T polymorphism was high. The results of this study do not provide evidence for association between the putatively functional SNPs 3G/A and 1249G/T and RD. 2013 Wiley Periodicals, Inc.

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关键词：

dyslexia chromosome 15q EKN1 genetics

DOI：

10.1002/ajmg.b.32123

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年份：

2013