摘要：

To assess the effect of calorie restriction equivalent to a 66% food restriction or social isolation on splenic immune responses, calorie-restricted five week-old male Wistar rats, pair fed controls individually caged and pair fed controls caged in groups, were studied for four weeks. Calorie restricted and isolated rats showed increased splenic concanavalin A response with peak activity during the activity span. Mean 24 h values of splenic lipopolysaccharide response decreased in isolated rats compared to grouped rats. The highest values of T cells occurred in calorie restricted rats and those of B cells in isolated rats. Mean values of splenic CD4 + and CD8 + cells augmented in isolated or calorie restricted groups. The highest in vitro interferon- production occurred in the isolated group and the lowest in the grouped rats, the differences among groups being significant. Both experimental procedures generally disrupted 24-h rhythmicity of splenic immune parameters. Mean values of plasma corticosterone were higher in calorie restricted rats than in isolated rats and both differed significantly from grouped rats. The results indicate that either calorie restriction or social isolation augmented cell-mediated immunity in rat spleen.

展开