X Chromosome Dosage Compensation: How Mammals Keep the Balance
摘要：
The development of genetic sex determination and cytologically distinct sex chromosomes leads to the potential problem of gene dosage imbalances between autosomes and sex chromosomes and also between males and females. To circumvent these imbalances, mammals have developed an elaborate system of dosage compensation that includes both upregulation and repression of the X chromosome. Recent advances have provided insights into the evolutionary history of how both the imprinted and random forms of X chromosome inactivation have come about. Furthermore, our understanding of the epigenetic switch at the X-inactivation center and the molecular aspects of chromosome-wide silencing has greatly improved recently. Here, we review various facets of the ever-expanding field of mammalian dosage compensation and discuss its evolutionary, developmental, and mechanistic components.
展开
DOI：
10.1016/S0376-7388(00)00395-1
被引量：
年份：
2008
国家科技图书文献中心
(权威机构)
掌桥科研
Semantic Scholar
万方医学
dx.doi.org
查看更多
NCBI
NCBI
Oxford Univ Press
Annual Reviews
Cell Press
Europe PMC
ResearchGate
(全网免费下载)
ResearchGate
ProQuest
EBSCO
学术范
mendeley.com
SAGE
academic.reed.edu
(全网免费下载)
rnajournal.cshlp.org
genetics.org
pubget.com
onAcademic
jme.endocrinology-journals.org
bvsalud.org
rstb.royalsocietypublishing.org
embor.embopress.org
pubfacts.com
reproduction-online.org
scienceopen.com
molbiolcell.org
mysciencework.com
advances.nutrition.org
mcb.asm.org
deepdyve.com
www.socolar.com
readcube.com
学术范
(全网免费下载)
reed.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
