Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.
摘要：
AR gene expression in CRPC is increased by an enhancer in the second intron This enhancer is repressed by AR at high androgen levels through LSD1 recruitment AR represses genes mediating androgen synthesis, DNA synthesis, and cell cycling Decreased androgen in CRPC relieves repression but supports AR-dependent growth
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关键词：
Cell Line, Tumor Humans Prostatic Neoplasms Histones Receptors, Androgen RNA, Messenger Androgens Gene Expression Regulation, Neoplastic Methylation Male
DOI：
10.1016/j.ccr.2011.09.001
被引量：
年份：
2011
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