Tobacco Smoke Carcinogens and Lung Cancer
摘要：
Cigarette smoking is the major cause of lung cancer, the largest cancer killer in the world. This chapter discusses the role of cigarette smoke carcinogens as causes of lung cancer. A general mechanistic framework is presented, in which cigarette smoke carcinogens and their metabolically activated forms cause mutations in critical growth control genes, along with other effects. Evidence and unresolved issues for the role of various groups of carcinogens, such as polycyclic aromatic hydrocarbons, nitrosamines, volatile organic compounds, and metals as causes of lung cancer are discussed. An overview of inhalation studies of cigarette smoke in laboratory animals is also presented. Collectively, the massive studies on carcinogenesis by cigarette smoke and its constituents provide a firm base for understanding the mechanisms of human lung carcinogenesis.
展开
关键词：
Animals Humans Lung Neoplasms Free Radicals Nitrosamines DNA Carcinogens Tobacco Smoke Pollution Smoking Mutation
DOI：
10.1007/978-1-61737-995-6_3
被引量：
年份：
2011
Taylor & Francis
Springer
BMJ
academic.oup.com
Semantic Scholar
(全网免费下载)
查看更多
万方医学
dx.doi.org
Ingenta
Oxford Univ Press
(全网免费下载)
NCBI
Europe PMC
BioMed Central
Oxford Univ Press
JBC
ResearchGate
EBSCO
Citeseer
(全网免费下载)
deepdyve.com
jn.nutrition.org
lungcancerjournal.info
jpet.aspetjournals.org
SAGE
readcube.com
science-open.com
mysciencework.com
experts.umn.edu
cebp.aacrjournals.org
erj.ersjournals.com
jacionline.org
mendeley.com
cghjournal.org
jco.ascopubs.org
physiolgenomics.physiology.org
theoncologist.alphamedpress.org
paperity.org
atvb.ahajournals.org
clinchem.org
scienceopen.com
fasebj.org
pubfacts.com
ar.iiarjournals.org
jvi.asm.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
