Concurrence of marginal zone B-cell lymphoma MALT-type and Langerhans cell histiocytosis in a thyroid gland with Hashimoto disease

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作者：

S Licci，A Boscaino，MD Palma，FD Nonno，A D'Antonio

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摘要：

Dear Editor, A 55-year-old woman presented with a clinical history of hypothyroidism and goiter with secondary obstructive symptoms, including dysphagia and stridor. On physical examination, the thyroid gland was diffusely enlarged, firm, with no pain on palpation, and no lymphadenopathy. The ultrasound study revealed a diffuse enlargement of the gland with no detectable calcifications. Laboratory tests were indicative of the Hashimoto's thyroiditis (HT). A fine needle aspiration revealed atypical follicular cells. The patient underwent an elective thyroidectomy. The thyroid gland was found to be diffusely enlarged with a firm, vaguely nodular, gray-yellowish cut surface in both lobes (Fig. 1a). The histological examination showed microscopic findings indicative of HT: broad bands of collagen separated lobules of thyroid tissue, which was heavily infiltrated by small lymphocytes, plasma cells, and lymphoid follicles with large germinal centers. The thyroid follicles were atrophic with an extensive oncocytic cell metaplasia. In the setting of HT, we observed the areas of diffuse effacement of the thyroid tissue with an extensive

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关键词：

Thyroid Gland mucosa-associated lymphoid tissue Lymphoma, B-Cell Histiocytosis, Langerhans-Cell 甲状腺淋巴瘤, B细胞组织细胞增多症, 郎格尔汉斯细胞

DOI：

10.1007/s00277-008-0489-5

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年份：

2008