Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells
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26
摘要：
Background The cyclin-dependent kinase (CDK) inhibitor p27<sup>Kip1</sup> is downregulated in a majority of human cancers due to ectopic proteolysis by the ubiquitin-proteasome pathway. The expression of p27 is subject to multiple mechanisms of control involving several transcription factors, kinase pathways and at least three different ubiquitin ligases (SCF<sup>SKP2</sup>, KPC, Pirh2), which regulate p27 transcription, translation, protein stability and subcellular localization. Using a chemical genetics approach, we have asked whether this control network can be modulated by small molecules such that p27 protein expression is restored in cancer cells.
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DOI：
10.1186/1741-7007-8-153
被引量：
年份：
2010
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Springer
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Semantic Scholar
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BioMed Central
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Pubmed Central
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BioMed Central
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BioMed Central
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Europe PMC
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ResearchGate
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Citeseer
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core.ac.uk
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