摘要：

Small cell lung cancer (SCLC) is a distinct and well-reproducible histopathological entity (Hirsch et al. 1982). Besides morphological criteria, SCLC is distinguished from other cell types by ultrastructural, endocrine, cytogenetic, cell-kinetic, and clinical findings (Gropp et al. 1980; Hattori et al. 1972; Whang-Peng et al. 1982). The high labeling index (Muggia et al. 1974; Pettengill et al. 1980) and short doubling time (Straus 1974; Weiss et al. 1970) are manifested clinically by fast growth, rapid onset of signs and symptoms, and a tendency toward early and widespread dissemination (Hansen et al. 1978; Muggia and Chevru 1974). Accordingly, the median survival time from diagnosis without treatment is 2.8 months, with only 4.2% of patients still alive at 1 year (Hyde et al. 1965; Zelen 1973).

展开