Induction of cell death by endogenous nerve growth factor through its p75 receptor
摘要：
DURING development, neuronal survival is regulated by the limited availability of neurotrophins, which are proteins of the nerve growth factor (NGF) family. Activation of specific trk tyrosine kinase receptors by the neurotrophins blocks programmed cell death. The trk A-specific ligand NGF has also been shown to activate the non-tyrosine kinase receptor p75, a member of the tumour necrosis factor (TNF) receptor and Fas (APO-1/CD95) family. Here we report that, early in development, endogenous NGF causes the death of retinal neurons that express p75 but not trk A. These results indicate that, as with cells of the immune system, the death of neurons in the central nervous system can also be induced by ligands and that the effect of NGF on cell fate depends on the type of receptor expressed by developing neurons.
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关键词：
Animals Neurons Chick Embryo Receptor, trkA Nerve Growth Factors Receptors, Nerve Growth Factor Receptor, Nerve Growth Factor Proto-Oncogene Proteins Ligands Immunologic Techniques
DOI：
10.1038/383166a0
被引量：
年份：
1996
BMJ
Springer
Nature
Nature
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万方医学
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