Axonal conduction and injury in multiple sclerosis: the role of sodium channels.
摘要：
Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Recent studies have implicated specific sodium channel isoforms as having an important role in several aspects of the pathophysiology of MS, including the restoration of impulse conduction after demyelination, axonal degeneration and the mistuning of Purkinje neurons that leads to cerebellar dysfunction. By manipulating the activity of these channels or their expression, it might be possible to develop new therapeutic approaches that will prevent or limit disability in MS.
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关键词：
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS CENTRAL-NERVOUS-SYSTEM CNS WHITE-MATTER RAT OPTIC-NERVE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS CEREBELLAR PURKINJE-CELLS SPINAL SENSORY NEURONS ANOXIC INJURY NITRIC-OXIDE MYELINATED AXONS
DOI：
10.1080/09537280903441518
被引量：
年份：
2006
Nature
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