JAKS AND STATS: Biological Implications*

来自 NCBI

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阅读量：

219

作者：

Leonard, Warren J.， O\"Shea, John J.

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摘要：

Cytokines and are molecules that play central roles in the regulation of a wide array of cellular functions in the lympho-hematopoietic system. These factors stimulate proliferation, differentiation, and survival signals, as well as specialized functions in resistance to pathogens. Although cytokines are known to activate multiple pathways that together mediate these important functions, one of these pathways, the Jak-pathway, is the focus of this chapter. This pathway is triggered by both cytokines and , and it very rapidly allows the of an signal into the . The pathway uses a novel mechanism in which cytosolic latent transcription factors, known as signal transducers and activators of transcription (), are tyrosine phosphorylated by family tyrosine kinases (Jaks), allowing dimerization and nuclear translocation. then can modulate the expression of target genes. The basic biology of this system, including the range of known Jaks and , is discussed, as are the in and lacking some of these molecules.

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关键词：

cytokines interferons signaling transcriptional activation tyrosine phosphorylation

DOI：

10.1146/annurev.immunol.16.1.293

被引量：

3019

年份：

1998