Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene
摘要：
Analysis of the organization and nucleotide sequence of two human loci related to the transforming gene of Kirsten murine sarcoma virus establishes one as a functional gene and the other as a processed pseudogene. The two final coding exons of the functional gene seem to have arisen by duplication. Differentially spliced mRNAs incorporating one or other of the duplicated exons probably served as the intermediates by which the viral transforming gene and the pseudogene were generated. This suggests that the functional gene may specify either of two related polypeptides depending on the pattern of RNA splicing.
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关键词：
Humans Sarcoma Viruses, Murine Kirsten murine sarcoma virus Cell Transformation, Viral Viral Proteins Cloning, Molecular Gene Expression Regulation RNA Processing, Post-Transcriptional RNA Splicing Amino Acid Sequence
DOI：
10.1038/304501a0
被引量：
年份：
1983
Taylor & Francis
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