Modulation of apoptosis by the widely distributed Bcl-2 homologueBak

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125

作者：

MC Kiefer，MJ Brauer，VC Powers，JJ Wu，SR Umansky，LD Tomei，PJ Barr

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摘要：

MEMBERSof the Bcl-2 family of proteins are characterized by their ability to modulate cell death. Bcl-2 and some of its homologues inhibit apoptosis 1–4 , whereas other family members, such as Bax, will accelerate apoptosis under certain conditions 5 . Here we describe the identification and characterization of a complementary DNA that encodes a previously unknown Bcl-2 homologue designated Bak. Like Bax, the bak gene product primarily enhances apoptotic cell death following an appropriate stimulus. Unlike Bax, however, Bak can inhibit cell death in an Epstein–Barr-virus-transformed cell line. The widespread tissue distribution of Bak messenger RNA, including those containing long-lived, terminally differentiated cell types, suggests that cell-death-inducing activity is broadly distributed and that tissue-specific modulation of apoptosis is controlled primarily by regulation of molecules that inhibit apoptosis.

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关键词：

Amino Acid Sequence Animals Apoptosis Base Sequence bcl-2 Homologous Antagonist-Killer Protein Cell Line Cell Line, Transformed DNA, Complementary Humans Hybrid Cells