DERIVATIVES OF CYCLODEXTRINS EXHIBITING ENHANCED AQUEOUS SOLUBILITY AND THE USE THEREOF

Sulfoalkyl ether cyclodextrin derivatives and their use as solubilizing agents for water insoluble drugs for oral, intranasal, or parenteral administration are disclosed.

STELLA Valentino J.，RAJEWSKI Roger - CA

Cyclodextrin complexation

The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-labile active ingredient which is a drug, cosmetic additive, food additive or agrochemical, comprising combining from about 0...

T Loftsson - US

New antiplatelet drugs: beyond aspirin and clopidogrel

SummaryAntiplatelet therapy remains a cornerstone of modern management of atherothrombotic vascular disease. For many years, aspirin has been the mainstay ...

A.，Siddique，M.，... - 《International Journal of Clinical Practice》

New antiplatelet drugs: beyond aspirin and clopidogrel.

Antiplatelet therapy remains a cornerstone of modern management of atherothrombotic vascular disease. For many years, aspirin has been the mainstay of init...

A Siddique，M Butt，E Shantsila，... - 《International Journal of Clinical Practice》

Repeat oral dosing of prasugrel, a novel P2Y12 receptor inhibitor, results in cumulative and potent antiplatelet and antithrombotic activity in several ani...

Antiplatelet and antithrombotic activity of multiple oral dosing of prasugrel were evaluated in several animal species. Prasugrel's active metabolite conce...

Y Niitsu，A Sugidachi，T Ogawa，... - 《European Journal of Pharmacology》

Disposition and metabolic fate of prasugrel in mice, rats, and dogs

The disposition and metabolism of prasugrel, a thienopyridine prodrug and a potent inhibitor of platelet aggregation in vivo, were investigated in mice, ra...

R.，L.，Smith，... - 《Xenobiotica》

Highly water soluble

Cyclodextrin derivatives having at least one group selected from among a sulfonic acid group, a sulfonic acid salt group, an ammonium salt group, a phospho...

M Yoshinaga - US

CYCLODEXTRINS WITH ANIONIC PROPERTIES

starch, whereupon a conversion to cyclodextrin occurs byenzymolysis. Procedures for making and isolating the cyThis application describes cyclodextrin derivatives hav clodextrins have been variously described as by F. Cr-amer ing ether s...

GLENN A. HULL，STANLEY M. PARMERTER，EARLE E. ALLEN JR.

Platelet Inhibition with Prasugrel and Increased Cancer Risks: Potential Causes and Implications

starch, whereupon a conversion to cyclodextrin occurs byenzymolysis. Procedures for making and isolating the cyThis application describes cyclodextrin derivatives hav clodextrins have been variously described as by F. Cr-amer ing ether s...

Serebruany，L V. - 《American Journal of Medicine》

Critical review of prasugrel for formulary decision makers.

BACKGROUND: Cardiovascular disease, including acute coronary syndromes (ACS) comprising ST-elevation and non-ST-elevation myocardial infarction (STEMI/NSTE...

J Schafer - 《J Manag Care Pharm》