A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.

来自 Nature

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作者：

BJ Fowlkes，AM Kruisbeek，H Ton-That，MA Weston，JE Coligan，RH Schwartz，DM Pardoll

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摘要：

Recent studies have demonstrated that CD3 is expressed on a subset of thymocytes with a CD4 CD8 (double negative) phenotype 1,2 . At least some of these cells bear the CD3-associated γδ T-cell receptor (TCR γδ) 3,4 . Here we describe a second subset of double negative thymocytes which expresses CD3-associated αβ receptors (TCR αβ). Surprisingly, these cells express predominantly the products of a single V β ; gene family (V β 8). These CD4 CD8 , TCRαβ + cells appear relatively late in ontogeny (between birth and day 5 of life) and thus are unlikely to be the precursors to the TCR αβ-bearing cells (CD4 + CD8 and CD4 CD8 + ) already present at birth. They can be selectively expanded in vitro by stimulation with a monoclonal antibody to V β 8 (F23.1) 5 in the presence of interleukin I (IL-1). We propose that this cell type is a unique T-cell population distinguishable from typical TCR αβ + T cells by its CD4 CD8 phenotype and a restricted TCR V β repertoire. Analysis of the unique phenotype of these cells suggests that they may represent the normal counterpart of the defective CD4 CD8 T cells found in the lpr autoimmune mouse.

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DOI：

10.1038/329251a0

被引量：

979

年份：

1987