Synthetic approaches to homogynolides A and B
摘要:
A four step, efficient and general methodology for the conversion of a cyclic ketone into the corresponding alpha-spiro-beta-methylene-gamma-butyrolactone, the key structural feature present in tricyclic sesquiterpenes bakkanes, has been developed employing a regiospecific 5-exo dig radical cyclisation reaction as the key step. The methodology has been extended to the total synthesis of bakkanes including homogynolide-B and chiral homogynolide-A.
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关键词:
Radical chain reactions Organic-synthesis Stereoselective synthesis Cyclization Bakkanes Strategy Alpina Design
DOI:
10.1351/pac199668030699
被引量:
年份:
1996






























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