Interaction of a Golgi-Associated Kinesin-Like Protein with Rab6
摘要：
Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.
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关键词：
Humans Microtubules Endoplasmic Reticulum Golgi Apparatus Hela Cells Kinesin rab GTP-Binding Proteins ras Proteins Alkaline Phosphatase Biological Transport
DOI：
10.1126/science.279.5350.580
被引量：
年份：
1998
万方医学
掌桥科研
NCBI
Europe PMC
NCBI
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