Protein S-nitrosylation: purview and parameters.
摘要:
S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain of cysteine, has emerged as an important mechanism for dynamic, post-translational regulation of most or all main classes of protein. S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.
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关键词:
Animals Humans Cell Membrane Nitrogen GTP Phosphohydrolases Sulfhydryl Compounds Cysteine Proteins Signal Transduction Oxidation-Reduction
DOI:
10.1038/nrm1569
被引量:
年份:
2005




































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