Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
摘要：
Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.
展开
关键词：
DOI：
10.1016/j.ccr.2009.03.027
被引量：
年份：
2009
Elsevier
(全网免费下载)
Elsevier
掌桥科研
万方医学
Semantic Scholar
(全网免费下载)
查看更多
dx.doi.org
NCBI
Cell Press
(全网免费下载)
Pubmed Central
(全网免费下载)
Cell Press
Europe PMC
NCBI
Oxford Univ Press
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
EBSCO
molecular-cancer.com
f1000.com
pubfacts.com
www.socolar.com
science-open.com
core.ac.uk
(全网免费下载)
bvsalud.org
ajpgi.physiology.org
mct.aacrjournals.org
mendeley.com
onAcademic
pubget.com
jlr.org
infona.pl
mysciencework.com
scienceopen.com
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
Cell Press
(全网免费下载)
Pubmed Central
(全网免费下载)
ResearchGate
(全网免费下载)
core.ac.uk
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
