The protein structures that shape caspase activity, specificity, activation and inhibition
摘要：
The morphology commonly known as results from a post-translational pathway driven largely by specific limited proteolysis. In the last decade the structural basis for regulation has moved from nothing to 'quite good', and we now know the fundamental structures of examples from the initiator phase, the pre-mitochondrial regulator phase, the executioner phase, inhibitors and their , and even the structures of some substrates. The field is as well advanced as the best known of proteolytic pathways, the cascade. Fundamentally new mechanisms in regulation have been disclosed. Structural evidence suggests that caspases have an unusual catalytic mechanism, and that they are activated by apparently unrelated events, depending on which position in the apoptotic pathway they occupy. Some naturally occurring caspase inhibitors have adopted classic inhibition strategies, but other have revealed completely novel mechanisms. All of the structural and mechanistic information can, and is, being applied to drive therapeutic strategies to combat overactivation of in , and underactivation in . We present a comprehensive review of the caspases, their regulators and inhibitors from a structural and mechanistic point of view, and with an aim to consolidate the many threads that define the rapid growth of this field.
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关键词：
Animals Humans Enzyme Precursors Caspases Protein Conformation Substrate Specificity Molecular Structure Amino Acid Sequence Molecular Sequence Data Models, Molecular
DOI：
10.1016/j.anucene.2008.10.005
被引量：
年份：
2004
国家科技图书文献中心
(权威机构)
掌桥科研
万方医学
Semantic Scholar
dx.doi.org
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