Synthesis of novel chiral tridentate aminophenol ligands for enantioselective addition of diethylzinc to aldehydes
摘要：
Novel chiral tridentate aminophenol ligand ( S)- 3a was obtained by a Mannich-type reaction of cresol, paraformaldehyde, and ( S)-1-(2-methoxyphenyl)-2-methylpropan-1-amine followed by a deprotection step. This tridentate aminophenol ligand shows high yield and enantioselectivity in the diethylzinc additions to a broad range of substrates, including alkyl, aryl, and α,β-unsaturated aldehydes.
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关键词：
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) C‐C bond formation organocatalysis alcohols (benzene compounds) alcohols (acyclic compounds)
DOI：
10.1016/j.tetasy.2008.06.027
被引量：
年份：
2008
Elsevier
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