Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

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作者：

ZI Bashir，S Alford，SN Davies，AD Randall，GL Collingridge

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摘要：

NEUROTRANSMISSION at most excitatory synapses in the brain operates through two types of glutamate receptor termed α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMP A) and N -methyl-D-aspartate (NMDA) receptors; these mediate the fast and slow components of excitatory postsynaptic potentials respectively 1–3 . Activation of NMDA receptors can also lead to a long-lasting modification in synaptic efficiency at glutamatergic synapses; this is exemplified in the CA1 region of the hippocampus, where NMDA receptors mediate the induction of long-term potentiation (LTP) 4 . It is believed that in this region LTP is maintained by a specific increase in the AMPA receptor-mediated component of synaptic transmission 5,6 . We now report, however, that a pharmacologically isolated NMDA receptor-mediated synaptic response can undergo robust, synapse-specific LTP. This finding has implications for neuropathologies such as epilepsy and neurodegeneration, in which excessive NMDA receptor activation has been implicated 7 . It adds fundamentally to theories of synaptic plasticity because NMDA receptor activation may, in addition to causing increased synaptic efficiency, directly alter the plasticity of synapses.

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关键词：

environmental factors environmental policy Recreation Tourism development

DOI：

10.1038/349156a0

被引量：

802

年份：

1991