Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact.
摘要：
Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.
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关键词：
Humans Colorectal Neoplasms Tissue Inhibitor of Metalloproteinase-1 Carcinoembryonic Antigen Neoplasm Proteins Tumor Markers, Biological Prospective Studies Preoperative Care Enzyme-Linked Immunosorbent Assay Adult
DOI：
10.1155/2006/173815
被引量：
年份：
2006
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